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The 12 Best Supplements for a Healthy Liver

Explore the 12 best supplements to support liver health, backed by research and practical benefits for optimal function.

By HealthyCrispy Editorial Updated Aug 2026 Evidence-reviewed

Maintaining liver health is crucial for overall wellness, as the liver plays a vital role in detoxification and metabolism. Supplements can support liver function, but it's essential to choose wisely based on scientific evidence.

This list ranks the 12 best supplements for a healthy liver, highlighting their benefits and practical considerations. Always consult with a healthcare professional before starting any new supplement regimen.

Part of our Fatty Liver hub.

1
Best overall

Milk Thistle Extract

★★★★★ 4.8

Milk thistle contains silymarin, a compound known for its antioxidant properties that may help protect liver cells from damage and support regeneration.

✔ Widely studied for liver health
✔ Natural antioxidant
− May interact with certain medications
Typically 140-600 mg per day Check price on Amazon →
2
Best value

N-Acetyl Cysteine (NAC)

★★★★★ 4.7

NAC is a potent antioxidant that helps replenish glutathione levels, essential for liver detoxification and reducing oxidative stress.

✔ Supports detoxification
✔ Reduces oxidative stress
− May cause gastrointestinal upset
Usually 600-1,800 mg daily Check price on Amazon →
3
Editor’s pick

Turmeric Extract (Curcumin)

★★★★★ 4.6

Curcumin, the active ingredient in turmeric, has anti-inflammatory and antioxidant properties that may help protect the liver from damage.

✔ Promotes liver health
✔ Anti-inflammatory effects
− Absorption can be low without black pepper
Commonly 500-2,000 mg per day Check price on Amazon →
4
Most versatile

Alpha-Lipoic Acid

★★★★★ 4.5

Alpha-lipoic acid is an antioxidant that can help reduce oxidative stress and improve insulin sensitivity, which supports liver function.

✔ May improve liver function
✔ Supports metabolic health
− Potential for skin rash in some individuals
Typically 300-600 mg daily Check price on Amazon →
5
Best for digestion

Artichoke Leaf Extract

★★★★☆ 4.4

Artichoke leaf extract may promote bile production, aiding digestion and helping the liver process fats more efficiently.

✔ Supports digestion
✔ May help lower cholesterol
− Limited research on long-term use
Usually 320-640 mg per day Check price on Amazon →
6
Best for inflammation

Omega-3 Fatty Acids

★★★★★ 4.6

Omega-3s are known to reduce inflammation and may help improve liver fat levels, supporting overall liver health.

✔ Supports cardiovascular health
✔ Reduces liver fat
− Can cause fishy aftertaste
About 1-3 grams daily Check price on Amazon →
7
Best herbal option

Dandelion Root

★★★★☆ 4.3

Dandelion root is traditionally used to support liver health and may help improve bile flow, aiding digestion and detoxification.

✔ Natural herbal remedy
✔ May help with digestion
− Limited clinical evidence
Typically 500-2,000 mg daily Check price on Amazon →
8
Best for energy

Coenzyme Q10 (CoQ10)

★★★★★ 4.5

CoQ10 supports energy production in liver cells and has antioxidant properties that can help protect the liver from oxidative stress.

✔ May enhance energy levels
✔ Supports heart health
− Can be expensive
Typically 100-300 mg daily Check price on Amazon →
9
Best antioxidant

Vitamin E

★★★★☆ 4.4

Vitamin E is a powerful antioxidant that may reduce inflammation in the liver, especially in individuals with fatty liver disease.

✔ Supports liver health
✔ Reduces oxidative stress
− High doses can be harmful
Commonly 400-800 IU daily Check price on Amazon →
10
Best mineral

Zinc

★★★★☆ 4.3

Zinc plays a crucial role in immune function and may help reduce liver inflammation and support overall liver health.

✔ Supports immune health
✔ May improve liver function
− Excessive intake can cause nausea
Usually 15-30 mg daily Check price on Amazon →
11
Best trace mineral

Selenium

★★★★☆ 4.2

Selenium is an essential trace mineral that has antioxidant properties, supporting liver health by protecting against oxidative damage.

✔ Supports antioxidant defense
✔ May improve liver function
− Can be toxic in high doses
Typically 55-200 mcg daily Check price on Amazon →
12
Best for energy metabolism

B-Complex Vitamins

★★★★☆ 4.3

B-complex vitamins are essential for energy metabolism and may support liver health by improving overall metabolic function.

✔ Supports energy metabolism
✔ Promotes overall health
− May cause mild stomach upset
Usually one tablet daily, as directed Check price on Amazon →

Key takeaways

  • Supplements can support liver health but should be chosen based on scientific evidence.
  • Consult with a healthcare professional before starting any new supplement.
  • Combining supplements with a balanced diet and healthy lifestyle is crucial for liver wellness.

Prices and availability are accurate as of publication. As an Amazon Associate, HealthyCrispy earns from qualifying purchases. This content is educational and not medical advice.